Date: 09/24/2025

FIRST is proud to announce the latest recipients of our Research Grant Program. These innovative projects represent the next wave of scientific discovery, aimed at improving understanding and treatment of ichthyosis and related skin disorders.

Through the support of our community, FIRST continues to fund pioneering research that addresses both the underlying biology of these rare conditions and their impact on quality of life. This year’s funded projects span a wide range of focus areas—from molecular mechanisms to patient health outcomes.

2025 Research Grant Recipients

  Xiaomin Bao, Northwestern 
Project Title: Molecular Mechanisms Linking Mechanical Stretch to Epidermolytic Ichthyosis Severity
Dr. Bao’s research will investigate how mechanical stress (such as skin stretching) contributes to the severity of epidermolytic ichthyosis, with the goal of identifying new therapeutic strategies.

Cheryl Bayart, Cinncinati Children's Hospital
Project Title: Evaluation of bone health and analysis of osteoporosis risk factors in patients with epidermal differentiation disorders (EDDs)
Dr. Bayart’s study will explore the connection between EDDs and bone health, evaluating risk factors for osteoporosis in this patient population.

  William Davies, Cardiff University, UK
Project Title: Understanding the biology of X-linked ichthyosis (XLI) and associated medical conditions with a new mouse model
Dr. Davies aims to develop and study a new mouse model for X-linked ichthyosis, shedding light on the biology of XLI and its associated medical challenges.

  John Edminister, Wake Forest
Project Title: Modulation of the Calcium-Sensing Receptor in Acantholytic Genodermatoses
Dr. Edminister’s research focuses on how the calcium-sensing receptor plays a role in acantholytic genodermatoses, potentially paving the way for targeted treatments.

    Keith Choate, Yale and Amy Paller, Northwestern (Second year funded)  
Project Title: Employing spatial transcriptomics to identify drivers of scaling and erythema in EDD
Drs. Choate and Paller will use advanced transcriptomic technologies to study what drives scaling and redness in epidermal differentiation disorders, helping to uncover new treatment targets.

Driving Progress Through Community Support

These projects highlight the power of research to move us closer to better treatments—and one day, cures—for ichthyosis and related skin conditions. FIRST is honored to support these investigators as they take bold steps toward improving the lives of individuals and families affected by these rare disorders.