Ichthyosis Genetics - 5

It would be lovely to say that healthy genes are always dominant over unhealthy ones, but unfortunately that is not the case. In several of the FIRST family of disorders, genes for the skin disorder are dominant and overshadow the genes for healthy skin. Epidermolytic hyperkeratosis (EHK) will be used as the example in this section, but the genetics also apply to all other autosomal dominant traits. Among the FIRST family of disorders, epidermolytic hyperkeratosis (EHK), keratitis-ichthyosis-deafness (KID) syndrome, pachyonychia congenita and Darier disease are some examples of dominant disorders following this inheritance pattern.


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