Ichthyosis Vulgaris is considered one of the five main types of ichthyosis (the others being lamellar Ichthyosis, congenital ichthyosiform erythroderma, X-linked ichthyosis and epidermolytic ichthyosis). Most varieties of ichthyosis affect only one person in several thousand or tens of thousands. Ichthyosis vulgaris, sometimes called common ichthyosis (“vulgar” means “common” in Latin), is the exception. It appears in approximately one person in every 250 to 300. The name is rarer than the disorder itself, which often goes undiagnosed because people who have it think that they have simple “dry skin” and never seek treatment.
unaffected. If the face is affected, the scaling is usually limited to the forehead and cheeks. Often, the skin on the palms of the hands and the soles of the feet is thickened and may have exaggerated lines. Babies with ichthyosis vulgaris often appear normal when they are born, but the skin abnormalities will almost always begin to show up by their first birthday. Ichthyosis vulgaris sometimes improves in certain climates or during the summer. Ichthyosis vulgaris also intends to improve with age.
Ichthyosis vulgaris was thought be caused by an autosomal dominant gene. If a person inherited the gene for ichthyosis vulgaris, the gene overshadowed the gene for normal skin and the person displayed the disease. However, researchers recently discovered that the disorder is semi-dominant. Profilaggrin (a protein that makes up most of the granules in the granular layer in the epidermis) was reduced or absent from the skin or people with vulgaris. Severely affected individuals have mutations in both copies of the profilaggrin gene, while people with only one copy of the mutated gene usually have a very mild skin problem.
Ichthyosis vulgaris is treated topically with moisturizers containing urea or glycerol. Lotions containing alpha-hydroxy acids may help. (For more information on which products contain these ingredients, refer to the Foundation’s Skin Care Products.) However, some individuals with ichthyosis vulgaris also experience atopic dermatitis (red, itchy patches of skin) and the alpha-hydroxy acids may irritate their skin.
This information is provided as a service to patients and parents of patients who have ichthyosis. It is not intended to supplement appropriate medical care, but instead to complement that care with guidance in practical issues facing patients and parents. Neither FIRST, its Board of Directors, Medical & Scientific Advisory Board, Board of Medical Editors nor Foundation staff and officials endorse any treatments or products reported here. All issues pertaining to the care of patients with ichthyosis should be discussed with a dermatologist experienced in the treatment of their skin disorder.
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