Ichthyosis Vulgaris
Other names: common ichthyosis, ichthyosis simplex
OMIM: 146700
Inheritance: autosomal dominant
Incidence: 1:250 - 1:5,000
Key findings:
- skin: fine, polygonal, flat whitish scales that may be darker on distal extremities; face and flexural areas usually spared; accentuated markings on palms and soles; often scaling around hair follicles on extremities
Associated findings: nasal allergies, asthma or eczema in >50%
Age at first appearance: early childhood; not usually present at birth
Long-term course: lifelong; marked seasonal variation; distinctly worse in dry climates
Diagnostic tests: skin biopsy can be highly suggestive, but not diagnostic
Abnormal gene: not known
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