Collodion Baby

Other names: None

OMIM: None

Inheritance: variable

Incidence: 1:100,000 (?)

Key findings:

  • skin: parchment-like covering of entire skin surface that cracks before or shortly after birth and then peels off in 2-4 weeks; eversion of eyelids (ectropion) and lips (eclabium) improves as collodion membrane shed

Associated findings: may be none; depends on the skin type causing the collodion membrane

Age at first appearance: birth

Long-term course: depends on underlying cause; most individuals have lifelong lamellar ichthyosis or congenital ichthyosiform erythroderma; some shed the collodion membrane and have no skin or other sequelae; some have trichothiodystrophy, X-linked recessive, neutral lipid storage disease, or Gaucher's disease.

Diagnostic tests: none

Abnormal gene: many


Clinicians seeking to confirm a diagnosis should visit FIRST's TeleIchthyosis site to submit a case to experts in ichthyosis.

To learn more about COLLODION BABY, follow this link.

Learn more about FIRST's Regional Support Network -  connecting affected individuals and families with each other. or calling the FIRST office at 800.545.3286.


This information is provided as a service to patients and parents of patients who have ichthyosis.  It is not intended to supplement appropriate medical care, but instead to complement that care with guidance in practical issues facing patients and parents.  Neither FIRST, its Board of Directors, Medical & Scientific Advisory Board, Board of Medical Editors nor Foundation staff and officials endorse any treatments or products reported here.  All issues pertaining to the care of patients with ichthyosis should be discussed with a dermatologist experienced in the treatment of their skin disorder.



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