Dr. Dina Ron, Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel
|Dr. Eli Sprecher|
UPDATE SEPTEMBER 2007
Drs. Sprecher and Ron are investigating the role of SNAP29 during normal and pathological skin differentiation. These investigators discovered two years ago that SNAP29 is a small protein involved in vesicle trafficking within cells of the upper layers of the skin. They have characterized the involvement of a protein related to SNAP29, VPS33B, in the pathogenesis of a complex type of ichthyosis called ARC syndrome. They have characterized the pattern of expression of SNAP29 in keratinocyte monolayers and in 3D-organotypic cultures, demonstrating that agents triggering skin maturation also induce SNAP 29 expression. They have generated cell lines lacking SNAP29, with which they intend to further dissect out the role of SNAP29 in the formation of the skin barrier. Finally, they have delineated the expression of SNAP29 in a number of skin diseases, finding out that SNAP29 expression is lost in squamous cell carcinoma and in many cases of lamellar ichthyosis.
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