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Proper diagnosis and a detailed investigation into family backgrounds can help a particular couple, working with a skilled doctor or genetic counselor, to determine their genetic odds. Even knowing the odds, a couple still plays a bit of genetic roulette, but there's a huge difference between the odds of one in two, one in four, or one in thousands. Proper genetic counseling, and subsequent genetic testing, can enable a couple to determine those odds accurately. Whether or not they decide to "play the odds" is, of course, a very personal decision.