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In the first FIRST family of disorders, lamellar ichthyosis, congenital ichthyosiform erythroderma (CIE), Netherton syndrome and Harlequin ichthyosis (among others) are caused by recessive genes – like the blue eyes example above. They are caused by recessive genes which ordinarily are dominated by genes for normal skin. Only when a person receives two recessive genes for lamellar ichthyosis or two for congenital ichthyosiform erythroderma or two for Harlequin ichthyosis (etc.) will he manifest one of these disorders. In this section, we will use lamellar ichthyosis as our example of the autosomal recessive mode of inheritance.